2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. TRP Channel
  5. TRPA Isoform
  6. TRPA Antagonist

TRPA Antagonist

TRPA Antagonists (6):

Cat. No. Product Name Effect Purity
  • HY-120689
    PF-04745637
    		Antagonist 99.97%
    PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1.
  • HY-172774
    TRPV1 antagonist 10
    		Antagonist
    TRPV1 antagonist 10 is an orally active and potent TRPV1 antagonist (IC50 = 33.06 nM), moderate to weak URAT1 (IC50 = 22.51 μM) and GLUT9 (60.25% at 50 μM) inhibitor. TRPV1 antagonist 10 has analgesic and urate-lowering effect. TRPV1 antagonist 10 can be studied for research in hyperuricemia and inflammatory pain.
  • HY-15065
    Chembridge-5861528
    		Antagonist 99.76%
    Chembridge-5861528 (TCS 5861528) is a potent TRPA1 channel antagonist that antagonizes similarly allyl isothiocyanate- and 4-HNE-evoked TRPA1 responses, with IC50 values of 14.3 μM and 18.7 μM, respectively. Chembridge-5861528 shows antihypersensitivity activities.
  • HY-115877
    GDC-0334
    		Antagonist
    GDC-0334 is a selective TRPA1 antagonist. GDC-0334 inhibits TRPA1 function on airway smooth muscle and sensory neurons by decreasing cough and allergic airway inflammation in rats and guinea pigs. GDC-0334 can be used for TRPA1-mediated diseases research, such as pain or asthma.
  • HY-104061
    AMG8788
    		Antagonist
    AMG8788 is a potent, selective, orally active antagonist of TRPM8 with an IC50 of 63.2 nM.
  • HY-104062
    AMG9678
    		Antagonist
    AMG9678 is a potent, selective, orally active antagonist of TRPM8 with an IC50 of 31.2 nM.